Pathways to the Development of the Aging Phenotype
by John Papaconstantinou

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Pathways to the Development of the Aging Phenotype explores the journey that all living things must eventually take. Using the definition that aging is a “multifactorial syndrome caused by multiple pathophysiological processes that occur simultaneously in multiple tissues of the aged,” Dr. John Papaconstantinou provides a wholistic look at aging, its causes, how it presents, and how aging syndromes can be treated. In addition, this book offers a deeper look at the effects of aging on individual organs. The aging heart, skeletal muscle, eye, skin, kidney, intestine, liver, pancreas, and adipose tissue are all covered, as well as an examination of the aging brain and neurodegenerative diseases such as Alzheimer’s, ALS, Parkinson’s, and Huntington’s disease. Other important subjects covered are the effects of social isolation and loneliness on aging, as well as the effects of sleep and other lifestyle choices. Throughout the book, Dr. Papaconstantinou provides information on current and promising research on aging and the treatment of aging syndromes, as well as the recent, exciting work on tissue regeneration that suggests aged tissues and organs can be reprogrammed to a juvenile phenotype. Pathways to the Development of the Aging Phenotype is an exciting addition to scientific and medical literature related to aging and will be an invaluable resource for medical students, professionals, and researchers looking to expand their knowledge in this field.

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Dr. John Papaconstantinou was born in Philadelphia, Pennsylvania and received a BA and MA in Biology at Temple University, and a PhD in Biochemistry at John Hopkins University. After several other faculty positions, Dr. Papaconstantinou joined the University of Texas Medical Branch, Department of Biochemistry and Molecular Biology, where today he is a tenured professor and the Bertha and Robert Bucksch Distinguished Research Professor of Molecular Gerontology. A beloved teacher, he has received multiple teaching awards, including the Palmer Sanders Professorship for Excellence in Teaching at UTMB. Dr. Papaconstantinou’s research has always been concerned with aging, and most recently, he has focused on the specific role of p38aMAPK kinase inflammation in the development of the aging phenotype. His research has been funded by several national entities, including the National Institute on Aging, and he has served on many national advisory councils related to aging. In addition, he has published over 200 peer-reviewed journal articles focused on understanding the molecular processes of aging. Dr. Papaconstantinou lives in Galveston, Texas. In his free time, he enjoys tennis, swimming, reading, and frequent visits to art museums.

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John Papaconstantinou